The closest thing to running barefoot from Nike is the Nike Free Run+ Running Shoe, a comfortable, highly flexible shoe that trains your feet to be stronger.
Designed with a full bootie, the Nike Free Run+ gives you a customized, barefoot-like feel during your run. The lightweight mesh upper features a seamless forefoot for exceptional comfort. Sipes across the top of the midsole encourage toes to flex and grip naturally, which engage muscles normally neglected in traditional footwear. The Nike Free Run+ Running Shoe has deep flex grooves that enhance the foot’s flexibility and stability.